Characteristics that increase the chance of developing osteoporosis or having fractures are called "risk factors" and include:
- Personal history of fracture as an adult, especially after age 50
- Current low bone mass
- Being female
- Being thin and/or having a small frame
- Advanced age
- Family history of osteoporosis in a first degree relative (parents or siblings)
- Estrogen deficiency as a result of menopause, especially early or surgically induced
- Abnormal absence of menstrual periods (amenorrhea)
- Anorexia nervosa
- Low lifetime calcium intake
- An inactive lifestyle
- Current cigarette smoking
- Excessive use of alcohol
- Excessive exercise, especially if associated with amenorrhea or being underweight
- Poor diet and/or malnutrition and/or disease causing malabsorption of food
- Having had a stroke
- Having dementia or Alzheimer's disease
- Vitamin D deficiency
- Use of oral Steroids (also called glucocorticoids or corticosteriods, such as prednisone)
- Use of Depo-Provera
- Use of some cancer chemotherapy medications
- Use of some anticonvulsants (antiseizure medications), particularly phenytoin or phenobarbital